ד"ר כפיר בן הרוש

ד"ר כפיר בן הרוש

Kfir received his B. Sc and M. Sc in chemical engineering, and Ph. D in Structural biology from Ben-Gurion University. His Ph. D studies was performed with Prof. Ohad Medalia. During that period, Kfir and colleagues decipher the architecture of nuclear lamin filaments assembled in vitro. Kfir was awarded the Lev Margulis Memorial Prize in the field of microscopy for that work. Currently, Kfir lab uses lamin proteins to build nano- to macroscopic biological materials. Overall, the lab seek to answer the following fundamental questions: What are the structural and mechanical properties of lamin proteins assemblies in health and disease? How does a single point mutation alter the architecture and mechanics of hierarchical structures assembled from nuclear lamins? The answer to these questions has broad ramifications, from a fundamental understanding of structure-function in protein materials to cell nucleus mechanics

 

פרופיל

הנדסה כימית
מרצה
אשדוד
אשדוד

אשדוד

בני ברית 130

קורות חיים

השכלה

2010 -2011           Weizmann Institute of Science, Rehovot, Israel

                               Postdoctoral studies, Department of Biological Chemistry

                               Project: "Structural characterization of membrane-bound FtsY-    ribosome complex of E. coli" 

                               Advisor: Prof. Eitan Bibi

 

2005 -2010          Ben Gurion University, Be'er Sheva, Israel

Kreitman Graduate School, Ph.D. Program, Department of Life   Sciences

Dissertation: "The structure and function of the nuclear lamin filaments"

                             Advisor: Prof. Ohad Medalia

 

 

 

 

2003-2005            Ben-Gurion University of the Negev, Israel

                              Chemical Engineering; M. Sc, August 2005, with distinction

                              Dissertation: “Catalytic properties of solid alkaline metal

                              hydroxides in oxidation of 1-phenylethanol to acetophenone”

                              Advisors: Prof. Moti Herskowitz and Prof. Adi Wolfson

 

2000-2003            Ben-Gurion University of the Negev, Israel

                              Chemical Engineering; B. Sc, June 2003, with honor

תחומי מחקר

Biomaterials
Biomechanics
Protein-based fibers
Intermediate filaments proteins
Lamin proteins
Structural biology (cryo electron microscopy)

קורסים

Introduction to chemical engineering I (material balance)
Introduction to chemical engineering II (energy balance)
Introduction to chemical engineering III (separation processes and thermochemistry)
Thermodynamics I (Mechanics)
Thermodynamics II (Solutions)
Fundamentals of heat transfer
Fundamentals of mass transfer
Introduction to statistics and process control
Design and analysis of experiments
Biomimcry and entrepreneurship
Chemical engineers at the Natural Gas Industry  

פרסומים

Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD, Medalia O. (2017) The molecular architecture of lamins in somatic cells. Nature. 543, 261-264.

 

Zingerman-Koladko I, Khayat M, Harapin J, Shoseyov O, Gruenbaum Y, Salman A, Medalia O, Ben-Harush K (2016) The assembly of C. elegans lamins into macroscopic fibers. J Mech Behav Biomed Mater. 63:35-43.

 

Bank EM, Ben-Harush K, Feinstein N, Medalia O, Gruenbaum Y. (2012) Structural and physiological phenotypes of disease-linked lamin mutations in C. elegans.  J Struct Biol. 177(1):106-12.

 

Zeytuni N, Ozyamak E, Ben-Harush K, Davidov G, Levin M, Gat Y, Moyal T, Brik A, Komeili A, Zarivach R. (2011) Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly. Proc Natl Acad Sci U S A., 108(33): E480-7.

 

Bank, EM., Ben-Harush, K., Wiesel-Motiuk, N., Barkan, R., Feinstein, N., Lotan, O., Medalia, O., Gruenbaum, Y. (2011) A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in C. elegans.  Mol Biol Cell, 22(15), 2716-28.

 

Ben-Harush, K., Maimon, T., Patla, I., Villa, E. and Medalia, O. (2010) Visualizing cellular processes at the molecular level by cryo-electron tomography. J Cell Sci, 123, 7-12.

 

Ben-Harush, K., Wiesel, N., Frenkiel-Krispin, D., Moeller, D., Soreq, E., Aebi, U., Herrmann, H., Gruenbaum, Y. and Medalia, O. (2009) The Supramolecular Organization of the C. elegans Nuclear Lamin Filament. J Mol Biol, 386, 1392-1402.

 

Taimen, P., Pfleghaar, K., Shimi, T., Moller, D., Ben-Harush, K., Erdos, M.R., Adam, S.A., Herrmann, H., Medalia, O., Collins, F.S., Goldman, A.E. and Goldman, R.D. (2009) A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S A., 106(49): 20788–20793.

 

Wolfson, A., Ben-Harush, K. and Herskowitz, M. (2009) Aerobic oxidation of benzylic alcohols with solid alkaline metal hydroxides. Kinetics and Catalysis, 51, 63-68.

 

Ben-Harush, K., Wolfson, A. and Herskowitz, M. (2006) Unexpected performance of solid alkaline metal hydroxides in liquid phase oxidation of 1-phenylethanol. Lett Org Chem, 3, 664-667.